Residents in the Syrian capital were seen cheering in the streets of Damascus, as the rebel factions heralded the departure of “tyrant” Assad and “declare the city of Damascus free”.

The president’s reported departure comes less than two weeks since the Islamist Hayat Tahrir al-Sham (HTS) group launched its campaign challenging more than five decades of rule by the Assad family.

“After 50 years of oppression under Baath rule, and 13 years of crimes and tyranny and (forced) displacement… we announce today the end of this dark period and the start of a new era for Syria,” the rebel factions said on Telegram.

Prime Minister Mohammed al-Jalali said he was ready to cooperate with “any leadership chosen by the Syrian people”.

The head of the Syrian Observatory for Human Rights, Rami Abdel Rahman, told AFP “Assad left Syria via Damascus international airport before the army security forces left” the facility.

AFP was unable to immediately confirm the report, which follows a source close to Hezbollah saying fighters from the key Assad ally had left their positions around Damascus.

HTS said their fighters broke into a jail on the outskirts of the capital, announcing an “end of the era of tyranny in the prison of Sednaya” which has become a by-word for darkest abuses of the Syrian regime.

The rapid developments in Damascus come only hours after HTS said they had captured the strategic city of Homs, on the way to the capital.

The defence ministry earlier denied that rebels had entered Homs, describing the situation there as “safe and stable”.

Homs lies about 140 kilometres (85 miles) north of the capital and was the third major city seized by the rebels who began their advance on November 27, reigniting a years-long war that had become largely dormant.