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Revolutionary TB Vaccine Breakthrough: Gates, Wellcome Boost Funding For Advancement
A groundbreaking milestone has been reached in the development of a revolutionary tuberculosis (TB) vaccine, M72/AS01E (M72). Wellcome and the Bill & Melinda Gates Foundation have generously provided substantial funding to support a Phase III clinical trial, propelling the potential impact of the vaccine on combatting the global TB crisis. This article delves into the remarkable advancements in TB vaccine research, highlighting the urgent need for innovative solutions to address this devastating disease.
The groundbreaking progress in the development of a revolutionary TB vaccine, M72/AS01E (M72) is taking the centre stage with substantial funding from Wellcome and the Bill & Melinda Gates Foundation, the vaccine aims to combat the global TB crisis, emphasizing the urgent need for new tools to save lives and reduce the burden of this devastating disease.
Tuberculosis (TB) remains one of the most lethal diseases worldwide, claiming approximately 4,300 lives daily, particularly among those living in impoverished conditions. In an extraordinary step towards tackling this infectious disease, Wellcome and the Bill & Melinda Gates Foundation have announced significant funding to drive the progress of a promising TB vaccine candidate called M72/AS01E (M72) through a Phase III clinical trial. If successful, M72 could become the first new vaccine in over a century capable of effectively preventing pulmonary TB, a severe form of active TB.
The Global Impact of Tuberculosis
TB poses a severe threat to global public health, with an estimated 10.6 million people falling ill and 1.6 million succumbing to the disease in 2021 alone. This infectious disease disproportionately affects individuals in low- and middle-income countries, especially those enduring impoverished living conditions, malnutrition, and limited access to healthcare. Alarmingly, nearly a quarter of the world’s population is estimated to carry the latent TB bacterium without displaying symptoms but are at risk of developing active TB.
M72 Vaccine: A Beacon Of Hope
The introduction of the M72 vaccine marks a significant breakthrough in the fight against TB. Wellcome has pledged up to US$150 million in funding, with the Bill & Melinda Gates Foundation covering the remaining US$400 million, to facilitate the Phase III clinical trial for M72. By investing in this potentially game-changing vaccine, these philanthropic organizations aim to mitigate the escalating threat of infectious diseases and protect the most vulnerable populations. Eliminating TB as a public health menace requires global collaboration, financial support, and political will.
Challenges And Limitations Of Current TB Vaccine
The current TB vaccine in use, bacille Calmette-Guérin (BCG), has been administered since 1921. While BCG provides protection against severe systemic forms of TB in infants and young children, its efficacy against pulmonary TB in adolescents and adults is limited. Given the rise in TB cases and deaths, innovative tools are urgently needed to combat this disease effectively.
The Urgency For New Tools
Bill Gates, co-chair of the Bill & Melinda Gates Foundation, emphasizes the pressing need for new tools to address the surging TB crisis. Investing in safe and effective TB vaccines, alongside innovative diagnostics and treatments, has the potential to revolutionize TB care, saving countless lives and significantly reducing the burden of this costly disease. Over 25 years, a vaccine with just 50% efficacy could prevent up to 76 million new cases of TB, saving 8.5 million lives and reducing the need for 42 million antibiotic treatments. Moreover, it could avert approximately US$41.5 billion in TB-related catastrophic household costs, primarily benefiting the world’s most impoverished and vulnerable communities, as highlighted by the World Health Organization (WHO
Unprecedented Progress Of The M72 Vaccine Candidate
Among the 17 TB vaccines currently under development, the M72 vaccine candidate has shown immense promise since its inception in the early 2000s. Spearheaded by GSK, in collaboration with Aeras and the International AIDS Vaccine Initiative (IAVI), the development of M72 has reached the proof-of-concept phase (Phase IIb). Notably, the Gates Foundation has played a crucial role in providing financial support for this groundbreaking research. During the Phase IIb trial, M72 exhibited an unprecedented 50% efficacy in reducing pulmonary TB among adults with latent TB infection, marking a significant breakthrough in decades of TB vaccine research.
The Envisioned Impact And Collaborative Efforts
Dr. Tedros Adhanom Ghebreyesus, the Director-General of WHO, acknowledges the importance of the Gates Foundation and Wellcome’s support in developing a new TB vaccine, highlighting the upcoming UN high-level meeting on TB as an opportunity for progress. These collaborative efforts and commitments demonstrate that concerted political and financial action can turn the tide on the TB crisis. Targeting adults and adolescents, who carry the majority of the TB burden, with an effective vaccine is crucial to reduce disease transmission and prevent avoidable deaths. WHO warmly welcomes the dedication of the Bill & Melinda Gates Foundation and Wellcome in advancing the development of this vaccine candidate while continuing to support broader vaccine development and access through the TB Vaccine Accelerator Council.
The Devastating Impact Of TB And The COVID-19 Pandemic
TB claims more lives annually than any other infectious disease, and the COVID-19 pandemic has further exacerbated the crisis. The pandemic has hindered the progress made over the past two decades in expanding access to TB prevention, testing, and treatment. In 2021, TB cases increased by 4.5% compared to the previous year, while fewer individuals received diagnoses or the necessary treatment. To achieve the United Nations Sustainable Development Goals’ target of an 80% reduction in the TB incidence rate by 2030, the development of new tools to combat this disease is imperative.
TB And Vulnerable Populations
TB poses a particularly grave threat to individuals living with HIV, accounting for one-third of deaths among HIV-positive individuals. Moreover, resource-limited areas and the world’s most vulnerable populations bear the brunt of this disease, with over 80% of TB cases and deaths occurring in low- and middle-income countries.
Investments In TB Research And Development
Over the past two decades, increased investment in research and development (R&D) has strengthened the TB innovation pipeline. Progress has been made in novel diagnostic tests, improved sample collection methods, and shorter drug regimens for both TB and drug-resistant TB. However, to truly eliminate TB as a global health burden, the development and deployment of an effective vaccine for adolescents and adults are paramount.
Accelerating Progress Through Research and Funding
Further investments in effective diagnostics, vaccines, and shorter drug regimens are crucial to expedite progress in combating TB. According to the Global Plan to End TB 2023-2030, an annual investment of over US$26 billion from 2023 to 2030 is required to scale up TB care and prevention services for all individuals in need. Additionally, TB R&D necessitates an extra US$5 billion per year during this period. Achieving these targets requires substantial global support, both in terms of financial backing and political will, to drive innovation, manufacture, and distribute a robust pipeline of TB diagnostics, treatments, and vaccines. This collective effort will save and protect millions of lives from the grip of TB.
Wellcome’s Commitment To Global Health Challenges
Wellcome remains steadfast in its commitment to supporting scientific endeavors that aim to address urgent health challenges on a global scale. With a focus on life, health, and well-being, Wellcome actively supports discovery research and takes on three major worldwide health challenges: mental health, infectious diseases, and the intersection of climate and health. By investing in cutting-edge research and fostering collaborations, Wellcome aims to find innovative solutions and drive progress in these critical areas.
The Milestone Funding for the M72 TB Vaccine Candidate
The recent announcement of funding from Wellcome and the Bill & Melinda Gates Foundation to advance the M72/AS01E (M72) TB vaccine candidate marks a significant milestone in the fight against tuberculosis. This substantial financial support will propel the Phase III clinical trial of the vaccine, which aims to evaluate its efficacy in preventing the progression from latent TB infection to active pulmonary TB. The trial, sponsored by the Bill & Melinda Gates Medical Research Institute, will be conducted in collaboration with TB clinical investigators across multiple sites in Africa and Southeast Asia.
The Potential of M72 Vaccine For A TB-Free Future
The M72 vaccine holds immense promise as a potential game-changer in the fight against TB. If successful, it could become the first new vaccine in over a century that effectively prevents pulmonary TB, a severe form of active TB. The urgent need for new tools to combat TB is evident due to the staggering global burden of the disease, with millions of cases and deaths each year. Effective vaccines, along with improved diagnostics and treatments, are crucial to reducing the burden of this costly disease and saving countless lives.
Collaboration, Investment, And Political Will
To overcome the challenges posed by TB, sustained investment in research and development, global collaboration, and political will are crucial. The Gates Foundation and Wellcome’s support for the M72 vaccine candidate is a testament to the power of collaborative efforts in tackling global health issues. By working together, we can pave the way for a future free from the burden of TB, saving lives and creating healthier communities worldwide.
The funding boost provided by Wellcome and the Bill & Melinda Gates Foundation has significantly advanced the development of the M72 TB vaccine candidate. This groundbreaking vaccine has the potential to revolutionize TB care and contribute to the global efforts in eliminating this devastating disease. However, the fight against TB requires continued investment, research, and collaboration to develop effective tools that can make a lasting impact. Together, we can work towards a TB-free future, where individuals around the world are protected from the grip of this deadly infectious disease.
Lere Olayinka, the Senior Special Assistant on New Media and Public Communications to Nyesom Wike, the former Governor of Rivers State and current Minister of the Federal Capital Territory (FCT), has responded to the recent appointment of Bashir Ojulari as the new Group Chief Executive Officer of the Nigerian National Petroleum Company Limited (NNPC Ltd.).
Olayinka took to X (formerly Twitter) to address discussions surrounding this leadership transition. His post aimed to clarify that President Bola Ahmed Tinubu did not dismiss Mele Kyari, a northerner, to replace him with a southerner, as some speculated. Instead, Olayinka pointed out that Ojulari, like Kyari, hails from the northern region of Nigeria.
According to Olayinka’s post on his official X account, he emphasised that Bashir Ojulari is from Kwara State, located in North Central Nigeria. Additionally, the new Board Chairman, Ahmadu Musa Kida, originates from Borno State in the North East.
His post stated: “Bashir Ojulari, the new NNPCL CEO, is a northerner from Kwara State, North Central Nigeria. The new Board Chairman, Ahmadu Musa Kida, is also a northerner, from Borno State, North East Nigeria.”
Olayinka’s statement came in response to narratives suggesting that the appointment was politically motivated to favour one region over another.
By Israel Bulus, Kaduna
The Middle Belt Forum (MBF) has strongly condemned the extrajudicial killing of 16 travelers in Uromi, Edo State, while warning against retaliatory violence targeting Southerners in Northern Nigeria.
In a press statement released on Tuesday, MBF Spokesman Luka Binniyat denounced inflammatory threats from individuals claiming to represent Northern interests in response to the killings.
Recalled that the victims, were allegedly armed hunters, traveling from Port Harcourt to Kano when they were attacked by a mob that accused them of being kidnappers.
“The MBF strongly condemns the unlawful killing of any Nigerian citizen, including those who lost their lives in Uromi,” the statement read. “However, we categorically reject any attempt to use this tragic incident as a pretext to unleash violence against Southerners residing in Northern Nigeria.”
The forum assured that the Middle Belt would not become a battleground for reprisals, emphasizing that it remains a safe haven for all law-abiding Nigerians. It urged community leaders and youths to remain vigilant and prevent any attempts to instigate violence, calling for anyone with such intentions to be handed over to authorities.
The MBF also reaffirmed its commitment to justice for all victims of violence across Nigeria. The statement highlighted the ongoing security challenges facing Middle Belt communities, citing persistent attacks by armed herdsmen with little government intervention.
” We hope that the swift response to the Uromi killings would serve as a precedent for broader action against criminal elements terrorizing the region.
“Thousands of our people remain in captivity, and vast portions of our land are still under the control of violent outlaws—primarily Fulani militants,” the statement noted.
“Justice must be served across the board.”
The MBF concluded by reiterating its support for the ongoing investigation into the Uromi incident and calling for a fair and decisive crackdown on all forms of criminality across the country.
BY ANKELI EMMANUEL, Sokoto
The Deputy Speaker, Sokoto State House of Assembly, Kabir Ibrahim kware, has commended governor Ahmed Aliyu for executing numerous developmental projects without taking loan from any financial institution.
Ibrahim Kware whp gave the commendation when he led other members of the State Assembly on Sallah homage to governor Aliyu, added that, the governor is very prudent in managing resources to achieve results.
“There was never a time you approached us with a request for permission to borrow money from any financial institutions whether at home or abroad,”he affirmed.
This , according to him, is worthy of commendation considering the myriad people- oriented projects the governor is executing across the state.
Speaking on behalf of the State’s Judiciary, Sokoto State Chief Judge, Justice Muhammad Sa’idu Sifawa, commended the governor for the construction of additional Court rooms at the State High Court.
Justice Sifawa also expressed delight over the way and manner the governor responds to issues affecting the Judiciary, which he said, is a clear testimony of the good working relationship existing between the three arms of government in the state.
Responding to the commendations, governor Ahmed Aliyu appealed for more synergy among the three tiers of government in the overall development of the state.
A statement by Abubakar Bawa, the Press Secretary to governor Alhmed Aliyu reaffirmed his principal’s unwavering commitment of the executive arm to providing the direly needed dividends of democracy to the people of the state,in line with his campaign promises.
The governor also urged lawmakers to present all the needs of their constituencies for prompt and diligent implementation.
“”I want to assure you that my doors are always open for you at any given time, to listen to the demands of your people.”
He reminded them on the need to put politics aside and work together with the executive arm for the progress and even development of the people they represent.
Turning to the members of the State Judiciary, the governor appealed to Judges and Khadis to ensure the quick dispensation of justice, so as to decongest the correctional centres.
“It is worrisome to see how inmates are languishing in correctional centres for minor offences in the name of awaiting trial.
“We recently appointed seven additional Judges and 7 Khadis, which is the first in the history of Sokoto State.
“The idea is to enhance the manpower in our Judiciary so as to speed up the dispensation of justice,” he added.
The governor further assured the members of the Judiciary of his administration’s readiness to ensure their welfare at all times.